{"product_id":"emlutini-ibrutinib-2","title":"Emlutini (Ibrutinib)","description":"Ibrutinib, sold under the brand name Emlutini, Imbruvica among others, is a small molecule drug that inhibits B-cell proliferation and survival by irreversibly binding the protein Bruton's tyrosine kinase (BTK). Blocking BTK inhibits the B-cell receptor pathway, which is often aberrantly active in B cell cancers. Ibrutinib is therefore used to treat such cancers, including mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenström's macroglobulinemia.\r\n\r\nIt is on the World Health Organization's List of Essential Medicines.\r\n\u003ch2\u003eMedical uses\u003c\/h2\u003e\r\nIbrutinib is used to treat chronic lymphocytic leukemia (CLL), Waldenström's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, marginal zone lymphoma, and chronic graft vs host disease. BTK inhibition by ibrutinib impairs the BCR signalling pathway, which is a key dependency of malignant B cells, but it has been shown that BTK inhibition also interferes with CD40 signalling, B cell adhesion and migration.\r\n\r\nIn the United States ibrutinib is indicated for the treatment of adults with mantle cell lymphoma (MCL) who have received at least one prior therapy, adults with chronic lymphocytic leukemia (CLL)\/small lymphocytic lymphoma (SLL) with or without 17p deletion, adults with Waldenström's macroglobulinemia (WM), adults with marginal zone lymphoma (MZL) who require systemic therapy and have received at least one prior anti-CD20-based therapy, adults with chronic graft versus host disease (cGVHD) after failure of one or more lines of systemic therapy.\r\n\r\nIt is a first line treatment in those with CLL who require treatment and are newly diagnosed.[11] It may also be used in CLL that relapses.\r\n\r\nWhy is this medication prescribed?\r\n\u003ch2\u003eIbrutinib is used\u003c\/h2\u003e\r\nto treat people with mantle cell lymphoma (MCL; a fast-growing cancer that begins in the cells of the immune system) who have already been treated with at least one other chemotherapy medication,\r\nto treat people with chronic lymphocytic leukemia (CLL; a type of cancer that begins in the white blood cells) and small lymphocytic lymphoma (SLL; a type of cancer that begins mostly in the lymph nodes),\r\nto treat people with Waldenstrom's macroglobulinemia (WM; a slow-growing cancer that begins in certain white blood cells in your bone marrow),\r\nto treat people with marginal zone lymphoma (MZL; a slow growing cancer that begins in a type of white blood cells that normally fights infection) who have already been treated with a certain type of chemotherapy medication,\r\nand to treat people with chronic graft vs host disease (cGVHD; a complication of hematopoietic stem-cell transplant [HSCT; a procedure that replaces diseased bone marrow with healthy bone marrow] that may start a while after the transplant and last for a long time) after being treated unsuccessfully with 1 or more medications.\r\nIbrutinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.\r\n\u003ch2\u003eHow should this medicine be used?\u003c\/h2\u003e\r\nIbrutinib comes as a capsule and a tablet to take by mouth. It is usually taken once daily. Take ibrutinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ibrutinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.\r\n\r\nSwallow the capsules whole with a glass of water; do not open, break, or chew them. Swallow the tablets whole with a glass of water; do not cut, crush or chew them.\r\n\r\nIf you are receiving obinutuzumab (Gazyva) injection or rituximab (Rituxan) injection, your doctor may tell you to take your dose of imbrutinib before you receive your injection.\r\n\r\nYour doctor may decrease your dose, or interrupt or discontinue your treament. This depends on how well the medication works for you and the side effects you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take ibrutinib even if you feel well. Do not stop taking ibrutinib without talking to your doctor.\r\n\r\nAsk your pharmacist or doctor for a copy of the manufacturer's information for the patient.\r\n\r\n\u003cstrong\u003eOther uses for this medicine\u003c\/strong\u003e\r\nThis medication may be prescribed for other uses; ask your doctor or pharmacist for more information.\r\n\u003ch2\u003eWhat side effects can this medication cause?\u003c\/h2\u003e\r\nIbrutinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:\r\ndiarrhea\r\nnausea\r\nconstipation\r\nvomiting\r\nstomach pain\r\nheartburn or indigestion\r\ndecreased appetite\r\nexcessive tiredness or weakness\r\nmuscle, bone, and joint pain\r\nmuscle spasms\r\nswelling of the hands, feet, ankles, or lower legs\r\nrash\r\nitching\r\nsores in the mouth and throat\r\nanxiety\r\ndifficulty falling asleep or staying asleep\r\ncough, runny or stuffed nose\r\nblurred vision\r\ndry or watery eyes\r\npink eye.","brand":"Tongmeng (Lao) Pharmaceutical \u0026 Food Co., Ltd.（TLPH）","offers":[{"title":"Default Title","offer_id":44797948133419,"sku":"RL1420230901356","price":0.0,"currency_code":"AMD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0701\/3528\/3755\/files\/2023-04-2083.png?v=1787022108","url":"https:\/\/xomeds.com\/products\/emlutini-ibrutinib-2","provider":"XOMEDS","version":"1.0","type":"link"}