{"product_id":"generic-apalutamide-apadx","title":"APADX (Apalutamide)","description":"\u003ch2\u003eAbout Apalutamide\u003c\/h2\u003e\u003cp\u003eApalutamide is a nonsteroidal antiandrogen medication used for the treatment of prostate cancer. It is an androgen receptor inhibitor. \u003c\/p\u003e\u003ch2\u003eProstate Cancer\u003c\/h2\u003e\u003cp\u003eIndicated for metastatic castration-sensitive prostate cancer (mCSPC) or nonmetastatic, castration-resistant prostate cancer (nmCRPC)\u003c\/p\u003e\u003cp\u003e240 mg PO qDay\u003c\/p\u003e\u003ch2\u003eDosage Modifications\u003c\/h2\u003e\u003ch3\u003eGrade ≥3 toxicity or intolerable adverse effect\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003ePermanently discontinue therapy for severe interstitial lung disease\/pneumonitis or if no other potential causes of ILD\/pneumonitis are identified, or confirmed SCARs, or for other Grade 4 skin reactions\u003c\/li\u003e\n\u003cli\u003eFor other adverse reactions when symptoms improve to Grade ≤1 or original grade, THEN\u003c\/li\u003e\n\u003cli\u003eResume at the same dose or a reduced dose (180 mg or 120 mg), if warranted\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eGrade 3-4 cerebrovascular and ischemic cardiovascular events\u003c\/h3\u003e\u003cul\u003e\u003cli\u003eConsider permanent discontinuation\u003c\/li\u003e\u003c\/ul\u003e\u003ch3\u003eConfirmed SCARS or Grade 4 skin reactions\u003c\/h3\u003e\u003cul\u003e\u003cli\u003ePermanently discontinue for confirmed severe cutaneous adverse reactions (SCARs) or other grade 4 skin reactions\u003c\/li\u003e\u003c\/ul\u003e\u003ch3\u003eRenal impairment\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003eMild-to-moderate (eGFR 30-89 mL\/min\/1.73 m\u003csup\u003e2\u003c\/sup\u003e): No clinical significant difference in pharmacokinetics\u003c\/li\u003e\n\u003cli\u003eSevere (eGFR ≤30 mL\/min\/1.73 m\u003csup\u003e2\u003c\/sup\u003e): Pharmacokinetics unknown\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eHepatic impairment\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003eMild-to-moderate (Child-Pugh A or B): No clinical significant difference in pharmacokinetics\u003c\/li\u003e\n\u003cli\u003eSevere (Child-Pugh C): Pharmacokinetics unknown\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"BIGBEAR Pharma, Laos PDR","offers":[{"title":"Default Title","offer_id":44797953409067,"sku":"RL3020241030","price":0.0,"currency_code":"AMD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0701\/3528\/3755\/files\/2024-10-2264.jpg?v=1787022201","url":"https:\/\/xomeds.com\/products\/generic-apalutamide-apadx","provider":"XOMEDS","version":"1.0","type":"link"}