{"product_id":"generic-selinexor-sailidx","title":"SALLYDX (Selinexor)","description":"Selinexor is used along with dexamethasone to treat multiple myeloma (a type of cancer of the bone marrow) that has returned or that did not respond to at least 4 other treatments.\r\n\u003ch3\u003eMultiple Myeloma\u003c\/h3\u003e\r\n\u003ch4\u003eIn combination with bortezomib and dexamethasone (SVd)\u003c\/h4\u003e\r\n\u003cul\u003e\r\n \t\u003cli\u003eIndicated, in combination with bortezomib and dexamethasone, for multiple myeloma (MM) have received ≥1 prior therapy\u003c\/li\u003e\r\n \t\u003cli\u003e\r\n\u003ch5\u003e35-day cycle\u003c\/h5\u003e\r\n\u003cul\u003e\r\n \t\u003cli\u003eSelinexor 100 mg PO qWeek on Day 1; continue until disease progression or unacceptable toxicity\u003c\/li\u003e\r\n \t\u003cli\u003eBortezomib 1.3 mg\/m\u003csup\u003e2\u003c\/sup\u003e SC qWeek on Day of each week x 4 weeks followed by 1 week off\u003c\/li\u003e\r\n \t\u003cli\u003eDexamethasone 20 mg PO twice weekly on Days 1 and 2 of each week\u003c\/li\u003e\r\n \t\u003cli\u003eRefer to prescribing information of bortezomib and dexamethasone for additional dosing information\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch4\u003eIn combination with dexamethasone (Sd)\u003c\/h4\u003e\r\n\u003cul\u003e\r\n \t\u003cli\u003eIndicated in combination with dexamethasone for adults with relapsed or refractory multiple myeloma (RRMM) who have received at least 4 prior therapies and whose disease is refractory to at least 2 proteasome inhibitors, at least 2 immunomodulatory agents, and an anti-CD38 monoclonal antibody\u003c\/li\u003e\r\n \t\u003cli\u003eSelinexor 80 mg PO plus dexamethasone 20 mg PO on Days 1 and 3 of each week\u003c\/li\u003e\r\n \t\u003cli\u003eContinue until disease progression or unacceptable toxicity\u003c\/li\u003e\r\n \t\u003cli\u003eRefer to prescribing information of dexamethasone for additional dosing information\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch3\u003eDiffuse Large B-Cell Lymphoma\u003c\/h3\u003e\r\nIndicated for relapsed or refractory diffuse large B-cell lymphoma (DLBCL), not otherwise specified, including DLBCL arising from follicular lymphoma, in patients previously treated with at least 2 lines of systemic therapy\r\n\r\n60 mg PO on Days 1 and 3 of each week\r\n\r\nContinue until disease progression or unacceptable toxicity\r\n\u003ch3\u003eDosage Modifications\u003c\/h3\u003e\r\n\u003ch4\u003eDosage reduction recommendations for adverse effects\u003c\/h4\u003e\r\n\u003cul\u003e\r\n \t\u003cli\u003e\r\n\u003ch5\u003eSVd\u003c\/h5\u003e\r\n\u003cul\u003e\r\n \t\u003cli\u003eStarting dose: 100 mg once weekly\u003c\/li\u003e\r\n \t\u003cli\u003eFirst reduction: 80 mg once weekly\u003c\/li\u003e\r\n \t\u003cli\u003eSecond reduction: 60 mg once weekly\u003c\/li\u003e\r\n \t\u003cli\u003eThird reduction: 40 mg once weekly\u003c\/li\u003e\r\n \t\u003cli\u003eFourth reduction: Permanently discontinue\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n \t\u003cli\u003e\r\n\u003ch5\u003eSd\u003c\/h5\u003e\r\n\u003cul\u003e\r\n \t\u003cli\u003eStarting dose: 80 mg on Days 1 and 3 each week (160 mg\/week)\u003c\/li\u003e\r\n \t\u003cli\u003eFirst reduction: 100 mg once weekly\u003c\/li\u003e\r\n \t\u003cli\u003eSecond reduction: 80 mg once weekly\u003c\/li\u003e\r\n \t\u003cli\u003eThird reduction: 60 mg once weekly\u003c\/li\u003e\r\n \t\u003cli\u003eFourth reduction: Permanently discontinue\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n \t\u003cli\u003e\r\n\u003ch5\u003eDLBCL\u003c\/h5\u003e\r\n\u003cul\u003e\r\n \t\u003cli\u003eStarting dose: 60 mg on Days 1 and 3 each week (120 mg\/week)\u003c\/li\u003e\r\n \t\u003cli\u003eFirst reduction: 40 mg Days 1 and 3 of each week (80 mg total per week)\u003c\/li\u003e\r\n \t\u003cli\u003eSecond reduction: 60 mg once weekly\u003c\/li\u003e\r\n \t\u003cli\u003eThird reduction: 40 mg once weekly\u003c\/li\u003e\r\n \t\u003cli\u003eFourth reduction: Permanently discontinue\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e","brand":"BIGBEAR Pharma, Laos PDR","offers":[{"title":"Default Title","offer_id":44797949542443,"sku":"RL1020230315900","price":0.0,"currency_code":"AMD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0701\/3528\/3755\/files\/2023-06-194.jpg?v=1787022130","url":"https:\/\/xomeds.com\/products\/generic-selinexor-sailidx","provider":"XOMEDS","version":"1.0","type":"link"}