{"product_id":"jiataile-sacituzumab-tirumotecan","title":"Jiataile (Sacituzumab Tirumotecan)","description":"\u003ch2\u003eAbout Sacituzumab tirumotecan\u003c\/h2\u003e\r\nSacituzumab tirumotecan, also known as sac-TMT, SKB264, or MK-2870, is an antibody-drug conjugate (ADC) being studied for various cancers, particularly non-small cell lung cancer (NSCLC) and breast cancer. It works by targeting and delivering a cytotoxic payload to cancer cells expressing the TROP2 protein.\r\n\r\nTROP2, a tumor-associated antigen expressed on many epithelial-derived tumors.The ADC binds to TROP2 on cancer cells, then releases a cytotoxic payload (an undisclosed topoisomerase I inhibitor) that inhibits tumor cell proliferation and causes cell death. Utilizes a unique Kthiol linker to attach the payload to the antibody, ensuring efficient delivery and release.\r\n\u003ch3\u003eApplications and Studies:\u003c\/h3\u003e\r\n\u003cstrong\u003eTriple-Negative Breast Cancer (TNBC)\u003c\/strong\u003e: Studies have shown a significant survival benefit in pretreated patients with advanced TNBC compared to chemotherapy.\r\n\r\n\u003ca href=\"https:\/\/www.onclive.com\/view\/sacituzumab-tirumotecan-earns-approval-in-china-in-pretreated-advanced-tnbc\"\u003e《Sacituzumab Tirumotecan Earns Approval in China in Pretreated Advanced TNBC》\u003c\/a\u003e\r\n\r\n\u003cstrong\u003eNon-Small Cell Lung Cancer (NSCLC)\u003c\/strong\u003e: Investigated in patients with advanced, previously treated NSCLC, including those with EGFR mutations.\r\n\r\n\u003ca href=\"https:\/\/www.onclive.com\/view\/china-s-nmpa-approves-sacituzumab-tirumotecan-for-pretreated-egfr-advanced-nsclc\"\u003e《China’s NMPA Approves Sacituzumab Tirumotecan for Pretreated EGFR+ Advanced NSCLC》\u003c\/a\u003e\r\n\r\nOther Cancers:Clinical trials are underway exploring the use of sacituzumab tirumotecan in other cancers, such as gastric cancer and endometrial cancer.","brand":"KELUN-BIOTECH, China","offers":[{"title":"Default Title","offer_id":44797957931051,"sku":"RL3520250508","price":0.0,"currency_code":"AMD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0701\/3528\/3755\/files\/2025-05-0735.png?v=1787022293","url":"https:\/\/xomeds.com\/products\/jiataile-sacituzumab-tirumotecan","provider":"XOMEDS","version":"1.0","type":"link"}