{"product_id":"lerar-lesinurad-200mg-2","title":"Generic (Lesinurad) Lerar","description":"\u003ch3\u003e\u003c\/h3\u003e\r\n\u003ch2\u003eMedication management\u003c\/h2\u003e\r\n\u003cdiv class=\"refsection_content\"\u003e\r\n\u003ch3\u003eOral administration\u003c\/h3\u003e\r\nLesinurad is used in combination with xanthine oxidase inhibitors such as allopurinol\r\n\r\nNot recommended for patients taking allopurinol \u0026lt;300 mg\/day (\u0026lt;200 mg\/day if estimated CrCl \u0026lt;60 mL\/min)\r\n\r\nConcomitant with morning dose of xanthine oxidase inhibitor\r\n\r\nIf treatment with a xanthine oxidase inhibitor is interrupted, lesinurad should also be interrupted\r\n\r\nPatients should be instructed to remain adequately hydrated (eg, 2 liters [68 ounces] of fluids per day)\r\n\r\nFailure to follow these instructions may increase the risk of kidney events.\r\n\r\n\u003chr\u003e\r\n\r\n\u003ch2\u003eAdverse reactions\u003c\/h2\u003e\r\n\u003cdiv class=\"refsection_content\"\u003e\r\n\u003ch3\u003e1-10%\u003c\/h3\u003e\r\n\u003cul\u003e\r\n \t\u003cli\u003eHeadache (5.3%)\u003c\/li\u003e\r\n \t\u003cli\u003eInfluenza (5.1%)\u003c\/li\u003e\r\n \t\u003cli\u003eGERD (2.7%)\u003c\/li\u003e\r\n \t\u003cli\u003eKidney failure (1.2%)\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch4\u003eserum creatinine\u003c\/h4\u003e\r\n\u003cul\u003e\r\n \t\u003cli\u003eIncreased creatinine (4.3%)\u003c\/li\u003e\r\n \t\u003cli\u003eAltitude 1.5 to \u0026lt;2 x baseline (3.9%)\u003c\/li\u003e\r\n \t\u003cli\u003eAltitude ≥ 2x baseline (1.8%)\u003c\/li\u003e\r\n \t\u003cli\u003eNearly 90% of students are resolved by the end of their studies\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch3\u003e\u0026lt;1%\u003c\/h3\u003e\r\n\u003cul\u003e\r\n \t\u003cli\u003ekidney stones\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003ch3\u003eHyperuricemia\u003c\/h3\u003e\r\nHyperuricemia associated with hypertension with xanthine oxidase inhibitor therapy in patients who do not achieve target serum uric acid levels with xanthine oxidase inhibitor alone\r\n\r\n200 mg orally once daily in combination with a xanthine oxidase inhibitor (ie, allopurinol or febuxostat)\r\n\r\nNot to exceed 200 mg\/day.\r\n\u003ch3\u003edose adjustment\u003c\/h3\u003e\r\n\u003ch4\u003erenal insufficiency\u003c\/h4\u003e\r\n\u003cul\u003e\r\n \t\u003cli\u003eCrCl≥45mL\/min: No dose adjustment required\u003c\/li\u003e\r\n \t\u003cli\u003eCrCl \u0026lt;45 mL\/min: do not use recinadide\u003c\/li\u003e\r\n \t\u003cli\u003eDiscontinue lacinadide if estimated CrCl persists \u0026lt;45 mL\/min.\r\n\r\n\u003chr\u003e\r\n\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch3\u003eDosage Considerations\u003c\/h3\u003e\r\nAssess renal function before starting treatment and periodically thereafter; monitor estimated CrCl \u0026lt;60 mL\/min more frequently\r\n\r\nNot recommended for the treatment of asymptomatic hyperuricemia\r\n\r\nDo not use as monotherapy; failure to take lacinadide with a xanthine oxidase inhibitor may increase the risk of adverse renal reactions\r\n\u003ch4\u003egout torch\u003c\/h4\u003e\r\n\u003cul\u003e\r\n \t\u003cli\u003eGout flares may occur after initiation of urate lowering therapy, including Rhine strains, due to the flow of urate from tissue deposits due to altered serum uric acid levels\u003c\/li\u003e\r\n \t\u003cli\u003eGout prophylaxis is recommended when starting lesinurad, according to practice guidelines\u003c\/li\u003e\r\n \t\u003cli\u003eDiscontinuation of lesinurad is not required if a gout flare occurs during treatment\u003c\/li\u003e\r\n \t\u003cli\u003eGout flares should be managed concurrently according to the needs of the patient\r\n\r\n\u003chr\u003e\r\n\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch2\u003estorage\u003c\/h2\u003e\r\nStore at 20-25°C (68-77°F); allowable temperature is 15-30°C (59-86°F).","brand":"Tongmeng (Lao) Pharmaceutical \u0026 Food Co., Ltd.（TLPH）","offers":[{"title":"Default Title","offer_id":44797947674667,"sku":"RL1420230901356","price":0.0,"currency_code":"AMD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0701\/3528\/3755\/files\/1663230184-c1f7e282dbf6e1e.png?v=1787022099","url":"https:\/\/xomeds.com\/products\/lerar-lesinurad-200mg-2","provider":"XOMEDS","version":"1.0","type":"link"}