{"product_id":"luciapro-aprocitentan","title":"LuciApro (Aprocitentan)","description":"\u003ch2\u003eAbout Aprocitentan\u003c\/h2\u003e\u003cp\u003eAprocitentan is a once-daily, orally active, dual endothelin receptor antagonist, which inhibits the binding of ET-1 to ETA and ETB receptors. Aprocitentan has a low potential for drug-drug interaction and a mechanism of action that is ideally suited for lowering blood pressure in adult patients whose hypertension is not adequately controlled by other drugs.\u003c\/p\u003e\u003ch3\u003eHypertension\u003c\/h3\u003e\u003cp\u003eIndicated for hypertension in combination with other antihypertensive drugs, to lower blood pressure in adult patients who are not adequately controlled on other drugs\u003c\/p\u003e\u003cp\u003e12.5 mg PO qDay\u003c\/p\u003e\u003ch3\u003eDosage Modifications\u003c\/h3\u003e\u003ch4\u003eRenal impairment\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eMild to severe (eGFR ≥15 mL\/min): No dose adjustment required\u003c\/li\u003e\n\u003cli\u003eKidney failure (eGRF \u0026lt;15 mL\/min) or hemodialysis: Not recommended\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eHepatic impairment\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eMild (Child-Pugh class A): No dose adjustment required\u003c\/li\u003e\n\u003cli\u003eModerate or severe (Child-Pugh class B or C): Not recommended\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eDosing Considerations\u003c\/h3\u003e\u003ch4\u003eBefore initiating and monitoring during treatment\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eConfirm a negative pregnancy test in females of reproductive potential before initiating, monthly during treatment, and 1 month after discontinuing\u003c\/li\u003e\n\u003cli\u003eMeasure hemoglobin before initiating and periodically during treatment as clinically indicated\u003c\/li\u003e\n\u003cli\u003eMeasure serum aminotransferase levels and total bilirubin before initiating and periodically during treatment as clinically indicated\u003c\/li\u003e\n\u003cli\u003eMonitor for signs and symptoms of fluid retention, weight gain, and worsening heart failure\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Lucius Pharmaceuticals (Lao) Co., Ltd","offers":[{"title":"Default Title","offer_id":44797955964971,"sku":"RL20250101s120","price":0.0,"currency_code":"AMD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0701\/3528\/3755\/files\/2024-12-1320.jpg?v=1787022246","url":"https:\/\/xomeds.com\/products\/luciapro-aprocitentan","provider":"XOMEDS","version":"1.0","type":"link"}