{"product_id":"odxibat-odevixibat","title":"Odxibat (Odevixibat)","description":"\u003ch2\u003eAbout Odevixibat\u003c\/h2\u003e\u003cp\u003eOdevixibat is a medication for the treatment of progressive familial intrahepatic cholestasis.  Odevixibat is a reversible, potent, selective inhibitor of the ileal bile acid transporter (IBAT).\u003cspan style=\"font-size: 13.3333px\"\u003e \u003c\/span\u003e\u003c\/p\u003e\u003cdiv class=\"collapse-more drug_expand\"\u003e\n\u003ch3\u003eDosage Forms \u0026amp; Strengths\u003c\/h3\u003e\n\u003ch4\u003ecapsule\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e400mcg\u003c\/li\u003e\n\u003cli\u003e1200mcg\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\u003ch3\u003eCholestasis-Induced Pruritus\u003c\/h3\u003e\u003cp\u003eIndicated for pruritus associated with progressive familial intrahepatic cholestasis (PFIC)\u003c\/p\u003e\u003cp\u003e40 mcg\/kg PO qAM\u003c\/p\u003e\u003ch4\u003eWeight-based dosing\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e45.5-55.4 kg: 2000 mcg PO qAM\u003c\/li\u003e\n\u003cli\u003e≥55.5 kg: 2400 mcg PO qAM\u003c\/li\u003e\n\u003cli\u003eIf no improvement after 3 months, may increase dose in 40-mcg\/kg increments up to 120 mcg\/kg\/day; not to exceed 6 mg\/day\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eAlagille Syndrome\u003c\/h3\u003e\u003cp\u003eIndicated for pruritus associated with Alagille syndrome (ALGS)\u003c\/p\u003e\u003cp\u003e120 mcg\/kg PO qAM\u003c\/p\u003e\u003ch4\u003eWeight-based dosing\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e45.5-55.4 kg: 6000 mcg PO qAM\u003c\/li\u003e\n\u003cli\u003e≥55.5 kg: 7200 mcg PO qAM\u003c\/li\u003e\n\u003c\/ul\u003e\u003cdiv id=\"plcHold-141\" class=\"adSpcHolder\"\u003e\u003cdiv id=\"ads-pos-141\" class=\"AdUnit globalpromoadsunit\"\u003e \u003c\/div\u003e\u003c\/div\u003e\u003ch3\u003eDosage Modifications\u003c\/h3\u003e\u003ch4\u003eTolerability for ALGS\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eConsider dose reduction to 40 mcg\/kg\/day if tolerability issues occur in absence of other causes\u003c\/li\u003e\n\u003cli\u003eIncrease to 120 mcg\/kg\/day once tolerability issues stabilize\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eHepatic impairment\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003ePatients with PFIC may have impaired hepatic function at baseline\u003c\/li\u003e\n\u003cli\u003ePatients with clinically significant portal hypertension or patients with decompensated cirrhosis: Safety and efficacy not established\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eLiver abnormalities\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eNew onset of elevated liver function tests (LFTs) or symptoms consistent with clinical hepatitis: Interrupt therapy; once LFTs either return to baseline or stabilize at a new baseline value, consider restarting at recommended dose, and increase as tolerated if appropriate\u003c\/li\u003e\n\u003cli\u003eElevated LFTs recur: Consider discontinuing permanently\u003c\/li\u003e\n\u003cli\u003eHepatic decompensation event (eg, variceal hemorrhage, ascites, hepatic encephalopathy) occurs: Permanently discontinue\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eDosing Considerations\u003c\/h3\u003e\u003ch4\u003eLimitation of use\u003c\/h4\u003e\u003cul\u003e\u003cli\u003eNot effective in PFIC type 2 patients with ABCB11 variants resulting in nonfunctional or complete absence of bile salt export pump protein\u003c\/li\u003e\u003c\/ul\u003e\u003ch4\u003eMonitoring parameters\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eLiver function tests (eg, ALT, AST, total bilirubin [TB], and direct bilirubin [DB]) and serum fat-soluble vitamins (FSV) levels: Baseline and during treatment\u003c\/li\u003e\n\u003cli\u003eInternational Normalized Ratio (INR): During treatment\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e \u003c\/p\u003e","brand":"Tongmeng (Lao) Pharmaceutical \u0026 Food Co., Ltd.（TLPH）","offers":[{"title":"Default Title","offer_id":44797957570603,"sku":"RL3320250406","price":0.0,"currency_code":"AMD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0701\/3528\/3755\/files\/2025-04-0350.jpg?v=1787022287","url":"https:\/\/xomeds.com\/products\/odxibat-odevixibat","provider":"XOMEDS","version":"1.0","type":"link"}