{"product_id":"ventok-10-venetoclax","title":"MOBODX (Mobocertinib)","description":"Mobocertinib is a small molecule tyrosine kinase inhibitor. Its molecular target is epidermal growth factor receptor (EGFR) bearing mutations in the exon 20 region.\r\n\u003ch3\u003eNon-Small Cell Lung Cancer\u003c\/h3\u003e\r\nIndicated for locally advanced or metastatic non–small cell lung cancer (NSCLC) in adults with epidermal growth factor receptor (EGFR) exon 20 insertion mutations and whose disease has progressed on or after platinum-based chemotherapy\r\n\r\n160 mg PO qDay\r\n\r\nContinue until disease progression or unacceptable toxicity\r\n\u003ch3\u003eDosage Modifications\u003c\/h3\u003e\r\n\u003ch4\u003eDose reductions for adverse reactions\u003c\/h4\u003e\r\n\u003cul\u003e\r\n \t\u003cli\u003eFirst dose reduction: 120 mg PO qDay\u003c\/li\u003e\r\n \t\u003cli\u003eSecond dose reduction: 80 mg PO qDay\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch3\u003eBlack Box Warnings\u003c\/h3\u003e\r\n\u003ch4\u003eQTc prolongation and torsades de pointes\u003c\/h4\u003e\r\n\u003cul\u003e\r\n \t\u003cli\u003eLife-threatening heart rate–corrected QTc prolongation, including torsades de pointes, may occur\u003c\/li\u003e\r\n \t\u003cli\u003eMonitor QTc and electrolytes periodically during treatment\u003c\/li\u003e\r\n \t\u003cli\u003eIncrease monitoring frequency in patients with risk factors for QTc prolongation (eg, congenital long QT syndrome, heart disease, electrolyte abnormalities)\u003c\/li\u003e\r\n \t\u003cli\u003eAvoid coadministration with drugs that may further prolong the QTc interval (eg, drugs known to prolong QTc interval, strong or moderate CYP3A inhibitors)\u003c\/li\u003e\r\n \t\u003cli\u003eWithhold, reduce dose, or permanently discontinue treatment based on the severity of QTc prolongation\u003c\/li\u003e\r\n\u003c\/ul\u003e","brand":"BIGBEAR Pharma, Laos PDR","offers":[{"title":"Default Title","offer_id":44797948100651,"sku":"RL11202300803600","price":0.0,"currency_code":"AMD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0701\/3528\/3755\/files\/2023-08-0551.jpg?v=1787022107","url":"https:\/\/xomeds.com\/products\/ventok-10-venetoclax","provider":"XOMEDS","version":"1.0","type":"link"}